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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AB3P
All Species:
39.09
Human Site:
Y358
Identified Species:
71.67
UniProt:
Q58FF7
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q58FF7
NP_031381
597
68325
Y358
E
T
Q
K
S
T
Y
Y
I
T
G
E
S
K
E
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
Y494
E
N
Q
K
H
I
Y
Y
I
T
G
E
T
K
D
Rhesus Macaque
Macaca mulatta
XP_001098219
597
68451
Y358
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Dog
Lupus familis
XP_532154
636
72879
Q397
I
S
R
E
M
L
Q
Q
S
K
I
L
K
V
I
Cat
Felis silvestris
Mouse
Mus musculus
P11499
724
83307
Y485
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Rat
Rattus norvegicus
P34058
724
83263
Y485
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518700
789
90657
Y577
E
T
Q
K
C
I
Y
Y
I
T
G
E
S
K
E
Chicken
Gallus gallus
Q04619
725
83409
Y486
E
S
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Frog
Xenopus laevis
NP_001086624
722
82939
Y483
E
N
Q
K
S
I
Y
Y
I
T
G
E
S
K
D
Zebra Danio
Brachydanio rerio
Q90474
725
83300
Y486
D
T
Q
K
H
I
Y
Y
I
T
G
E
T
K
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
F478
D
N
Q
K
H
V
Y
F
I
T
G
E
S
K
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
Y463
E
N
Q
T
Q
I
Y
Y
I
T
G
E
S
K
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P55737
699
80046
Y464
E
G
Q
N
D
I
F
Y
I
T
G
E
S
K
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
69
95.8
83.6
N.A.
78.4
78.8
N.A.
67.5
74.7
73.5
66.3
N.A.
64
N.A.
61.9
N.A.
Protein Similarity:
100
76.2
97.8
86
N.A.
80.3
80.6
N.A.
70.3
79
78.3
75.3
N.A.
73.2
N.A.
73.5
N.A.
P-Site Identity:
100
66.6
93.3
0
N.A.
93.3
93.3
N.A.
86.6
86.6
80
66.6
N.A.
60
N.A.
66.6
N.A.
P-Site Similarity:
100
80
93.3
20
N.A.
93.3
93.3
N.A.
86.6
93.3
86.6
86.6
N.A.
80
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
57
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
71.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
16
0
0
0
8
0
0
0
0
0
0
0
0
0
39
% D
% Glu:
77
0
0
8
0
0
0
0
0
0
0
93
0
0
47
% E
% Phe:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
93
0
0
0
0
% G
% His:
0
0
0
0
24
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
77
0
0
93
0
8
0
0
0
8
% I
% Lys:
0
0
0
77
0
0
0
0
0
8
0
0
8
93
8
% K
% Leu:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
31
0
8
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
93
0
8
0
8
8
0
0
0
0
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
16
0
0
47
0
0
0
8
0
0
0
77
0
0
% S
% Thr:
0
47
0
8
0
8
0
0
0
93
0
0
16
0
0
% T
% Val:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
85
85
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _